Subclassification of brain tumors based on ex vivo MRS metabolic profiles
نویسندگان
چکیده
T. E. Sjøbakk, S. Gulati, M. Gulati, S. Lundgren, S. H. Torp, and I. S. Gribbestad Dept. of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, St.Olavs University Hospital, Trondheim, Norway, Dept. of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway, Dept. of Oncology, St. Olavs University Hospital, Trondheim, Norway, Dept. of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway, Dept. of Pathology and Medical Genetics, St.Olavs University Hospital, Trondheim, Norway
منابع مشابه
Accurate Brain Tumor Biopsy Using 3D H-MRS Neuronavigation
Introduction: H-Magnetic Resonance Spectroscopy (H-MRS) is a tool that permits diagnosing types of intracranial tumors based on metabolite markers [1]. NMR (ex-vivo) of brain tumor samples has shown that the aggressiveness of a tumor may be determined based on its spectral profile [2]. Due to the heterogeneous nature of the tissue in brain tumors, it is thought that the metabolite profile diffe...
متن کاملMolecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers.
Brain tumors are one of the leading causes of death in adults with cancer; however, molecular classification of these tumors with in vivo magnetic resonance spectroscopy (MRS) is limited because of the small number of metabolites detected. In vitro MRS provides highly informative biomarker profiles at higher fields, but also consumes the sample so that it is unavailable for subsequent analysis....
متن کاملEx vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra VITALIANO TUGNOLI1, LUISA SCHENETTI2, ADELE MUCCI2, FRANCESCA PARENTI2, RITA CAGNOLI2, VALERIA RIGHI1,2, ANDREA TRINCHERO1, LUCA NOCETTI3, CRISTIAN TORACI3, LUCIANO MAVILLA4, GIANPAOLO
We report on the magnetic resonance spectroscopy (MRS) characterisation of different human meningiomas. Three histological subtypes of meningiomas (meningothelial, fibrous and oncocytic) were analysed both through in vivo and ex vivo MRS experiments. The ex vivo high-resolution magic angle spinning (HR-MAS) investigations, permitting an accurate description of the metabolic profile, are very he...
متن کاملVerification of the Accuracy of the Delivered Dose in Brain Tumors by in Vivo Dosimetry Using Diode Detectors
Introduction: During radiotherapy, high accuracy in the dose delivery is required because there is a strong relationship between the absorbed dose, local tumor control and particularly the normal tissue damage. In many institutions, in vivo dosimetry using diodes is performed to check the actual dose delivered. In general, the uncertainty in the dose delivered should fall within ± 5% of the...
متن کاملDetection of Glioblastoma Multiforme Tumor in Magnetic Resonance Spectroscopy Based on Support Vector Machine
Introduction: The brain tumor is an abnormal growth of tissue in the brain, which is one of the most important challenges in neurology. Brain tumors have different types. Some brain tumors are benign and some brain tumors are cancerous and malignant. Glioblastoma Multiforme (GBM) is the most common and deadliest malignant brain tumor in adults. The average survival rate for peo...
متن کامل